SoloCodigo

DataGridTableStyle tableStyle = new DataGridTableStyle();
tableStyle.MappingName = "Prog";
tableStyle.RowHeadersVisible = true;
tableStyle.RowHeaderWidth = 20;

DataGridTextBoxColumn column_x = new DataGridTextBoxColumn();
column_x.MappingName =  "nombre";
column_x.HeaderText = "Nombre";
column_x.Width = 100;
column_x.ReadOnly =true;
tableStyle.GridColumnStyles.Add(column_x);

// estilo para la fila editable

DataGridTextBoxColumn column_e = new DataGridTextBoxColumn();
column_e.MappingName =  "Editable";
column_e.HeaderText = "Editable";
column_e.Width = 100;
tableStyle.GridColumnStyles.Add(column_e);

Grid.TableStyles.Clear();
Grid.TableStyles.Add(tableStyle);